High-sugar diet can damage the gut, intensifying risk for colitis — ScienceDaily


Mice fed diets excessive in sugar developed worse colitis, a kind of inflammatory bowel illness (IBD), and researchers inspecting their massive intestines discovered extra of the micro organism that may harm the intestine’s protecting mucus layer.

“Colitis is a serious public well being downside within the U.S. and in different Western international locations,” says Hasan Zaki, Ph.D., who led the examine that seems in at the moment’s Science Translational Drugs. “This is essential from a public well being perspective.”

Colitis may cause persistent diarrhea, stomach ache, and rectal bleeding. The variety of American adults affected by IBD (which incorporates Crohn’s illness) jumped from 2 million in 1999 to three million in 2015, in keeping with the Facilities for Illness Management and Prevention. As well as, colitis is starting to indicate up in kids, who traditionally didn’t endure from it, says Zaki, a UT Southwestern assistant professor of pathology.

Due to the illness’s a lot greater prevalence in Western international locations, researchers have appeared to the Western-style food plan — excessive in fats, sugar, and animal protein — as a doable danger issue, says Zaki. Whereas high-fat diets have been discovered to set off IBD, the function of sugar has been extra controversial, he says.

This new examine factors to sugar — notably the glucose present in excessive fructose corn syrup developed by the meals business within the 1960s after which more and more used to sweeten smooth drinks and different meals — as a main suspect. “The incidence of IBD has additionally elevated in Western international locations, notably amongst kids, over this identical interval,” in keeping with the examine.

UT Southwestern researchers fed mice an answer of water with a 10 % focus of varied dietary sugars — glucose, fructose, and sucrose — for seven days. They discovered that mice that have been both genetically predisposed to develop colitis, or these given a chemical that induces colitis, developed extra extreme signs in the event that they have been first given sugar.

The researchers then used gene-sequencing strategies to establish the categories and prevalence of micro organism discovered within the massive intestines of mice earlier than and after receiving their sugar routine. After being given sugar remedies for seven days, these fed sucrose, fructose, and — particularly — glucose confirmed important adjustments within the microbial inhabitants contained in the intestine, in keeping with the examine.

Micro organism identified to provide mucus-degrading enzymes, equivalent to Akkermansia, have been present in higher numbers, whereas another varieties of bugs thought-about good micro organism and generally discovered within the intestine, equivalent to Lactobacillus, turned much less ample.

The researchers noticed proof of a thinning of the mucus layer that protects the liner of the massive gut in addition to indicators of an infection by different micro organism. “The mucus layer protects intestinal mucosal tissue from infiltration of intestine microbiota,” the examine explains. “Increased abundance of mucus-degrading micro organism, together with Akkermansia muciniphila and Bacteroides fragilis, in glucose-treated mice is, subsequently, a possible danger for the intestinal mucus barrier.

“As a result of erosion of the mucus layer, intestine micro organism have been in shut proximity with the epithelial layer of the massive gut in glucose-treated mice,” the examine continues. “Breaching of the epithelial barrier is the important thing initiating occasion of intestinal irritation.”

Though glucose had the best impact, “all three easy sugars profoundly altered the composition of intestine microbiota,” the examine reviews. Earlier research have proven that intestine microbiota of each people and mice can change quickly with a change in food plan. “Our examine clearly exhibits that you simply actually need to thoughts your meals,” says Zaki.

After discovering adjustments within the intestine microbiota in sugar-fed mice, the researchers fed feces from the sugar-treated mice to different mice. These mice developed worse colitis, suggesting that glucose-induced susceptibility to colitis could be transmitted together with the damaging intestinal microbiota from affected animals.

Zaki says he now plans to review whether or not and the way excessive sugar consumption impacts the event of different inflammatory illnesses equivalent to weight problems, fatty liver illness, and neurodegenerative illnesses like Alzheimer’s.



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