Clinical trial reverses two biological processes associated with aging in human cells — ScienceDaily


A brand new examine from Tel Aviv College (TAU) and the Shamir Medical Middle in Israel signifies that hyperbaric oxygen remedies (HBOT) in wholesome getting old adults can cease the getting old of blood cells and reverse the getting old course of. Within the organic sense, the adults’ blood cells truly develop youthful because the remedies progress.

The researchers discovered {that a} distinctive protocol of remedies with high-pressure oxygen in a strain chamber can reverse two main processes related to getting old and its sicknesses: the shortening of telomeres (protecting areas situated at each ends of each chromosome) and the buildup of outdated and malfunctioning cells within the physique. Specializing in immune cells containing DNA obtained from the individuals’ blood, the examine found a lengthening of as much as 38% of the telomeres, in addition to a lower of as much as 37% within the presence of senescent cells.

The examine was led by Professor Shai Efrati of the Sackler Faculty of Medication and the Sagol Faculty of Neuroscience at TAU and Founder and Director of the Sagol Middle of Hyperbaric Medication on the Shamir Medical Middle; and Dr. Amir Hadanny, Chief Medical Analysis Officer of the Sagol Middle for Hyperbaric Medication and Analysis on the Shamir Medical Middle. The medical trial was carried out as a part of a complete Israeli analysis program that targets getting old as a reversible situation.

The paper was printed in Getting old on November 18, 2020.

“For a few years our group has been engaged in hyperbaric analysis and remedy — remedies primarily based on protocols of publicity to high-pressure oxygen at varied concentrations inside a strain chamber,” Professor Efrati explains. “Our achievements over time included the development of mind capabilities broken by age, stroke or mind damage.

“Within the present examine we wished to look at the influence of HBOT on wholesome and impartial getting old adults, and to find whether or not such remedies can decelerate, cease and even reverse the conventional getting old course of on the mobile stage.”

The researchers uncovered 35 wholesome people aged 64 or over to a collection of 60 hyperbaric periods over a interval of 90 days. Every participant offered blood samples earlier than, throughout and on the finish of the remedies in addition to a while after the collection of remedies concluded. The researchers then analyzed varied immune cells within the blood and in contrast the outcomes.

The findings indicated that the remedies truly reversed the getting old course of in two of its main points: The telomeres on the ends of the chromosomes grew longer as a substitute of shorter, at a fee of 20%-38% for the totally different cell varieties; and the proportion of senescent cells within the general cell inhabitants was lowered considerably — by 11%-37% relying on cell kind.

“In the present day telomere shortening is taken into account the ‘Holy Grail’ of the biology of getting old,” Professor Efrati says. “Researchers all over the world are attempting to develop pharmacological and environmental interventions that allow telomere elongation. Our HBOT protocol was in a position to obtain this, proving that the getting old course of can actually be reversed on the primary cellular-molecular stage.”

“Till now, interventions akin to way of life modifications and intense train had been proven to have some inhibiting impact on telomere shortening,” Dr. Hadanny provides. “However in our examine, solely three months of HBOT had been in a position to elongate telomeres at charges far past any at present out there interventions or way of life modifications. With this pioneering examine, we now have opened a door for additional analysis on the mobile influence of HBOT and its potential for reversing the getting old course of.”

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Materials offered by American Friends of Tel Aviv University. Observe: Content material could also be edited for type and size.



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